"What has been entrusted to me" is our salvation, in other words, the deposit we have from God to walk with Him eternally.
"Satan does not venture to suggest this thought in a direct form, that God cannot fulfill, or is prevented from fulfilling, what he has promised... but, by preoccupying our eyes and understandings, he takes away from us all sense of the power of God." -John Calvin, Commentary on 2 Tim. 1:12
My women's discipleship group is studying 2 Timothy and this quote from Calvin about Satan's methods really hit me. It's a daily battle to guard our eyes and minds from being distracted, but we can take heart that our God is strong enough to keep our focus on Him. He IS able to guard our salvation no matter how far our eyes stray, He is greater than all. Amen!
John 10:29 "My Father, who has given them [you, Christian] to me, is greater than all,"
-Christy